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@danb
I have a pair of Loake 290 Chelsea boots which are Last 010 / F Fitting in 9.5 and normally take a 10 (45 in Sidis..)
They are a touch too narrow for my right little toe so I have barely ever worn them :(
Given my experience with that last I would say that their sizing seems to be fairly true to size - I definetly regret going down half a size. I went down a size as I have thin ankles/heels but normal ish width forefoot.