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@hugo7
Geo here: http://www.giant-bicycles.com/en-us/bikes/model/defy.5/9014/48856/
I guess the first number/reference size is the seat tube.
Xs/43.0 | 51.5
s/46.5 | 53
m/50.0 | 54.5
*I *doubt that you will need a 54.5cm. 53cm sounds in the right ballpark. The advantage with that is it has a normal seat post so there's some flexibly for you to get an inline or one with more layback if you need it.
Never be tempted to go for a bike that's too big. Especially if you're paying for a new bike.