Accommodating the 2" tyres means you lose out on the following:
Ideal trail (unless you're prepared to be super slack on the 2 inchers).
Ideal front centre (unless you're prepared to have toe overlap on the 2 inchers).
Ideal BB height (unless you're prepared to have a much higher centre of gravity on the 2 inchers).
Ideal tight rear-end.
The above also has a knock-on effect on your wheelbase and the shortest possible top tube you can achieve. A short top tube is good (in my opinion) as you can then stick on a long stem and achieve better weight distribution (good in the corners).
Accommodating the 2" tyres means you lose out on the following:
Ideal trail (unless you're prepared to be super slack on the 2 inchers).
Ideal front centre (unless you're prepared to have toe overlap on the 2 inchers).
Ideal BB height (unless you're prepared to have a much higher centre of gravity on the 2 inchers).
Ideal tight rear-end.
The above also has a knock-on effect on your wheelbase and the shortest possible top tube you can achieve. A short top tube is good (in my opinion) as you can then stick on a long stem and achieve better weight distribution (good in the corners).
All food for thought...