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@gbj_tester
In general, no. LF* (which stands for Large Flange) only makes a difference if the spokes are not tangential, and the difference it makes is barely worth having. SF (which stands for Small Flange) has essentially the same bracing angle when tangentially spoked, so axial stiffness of the wheel remains the same. On a rear wheel, the extra distance of the spoke hole from the axle does increase torsional stiffness slightly, and it's just about possible to see that using a lower crossing number with a LF rear hub will get you equal torsional stiffness to a SF hub and a little more axial stiffness, but people seem to manage just fine without this marginal improvement. In the end, choosing LF hubs is a 99% aesthetic decision.
*Merkins us LF for Low Flange and HF for High Flange, but they are idiots and should not be encouraged.