In the Middle Ages it was believed that when a person was writing with their left hand they were possessed by the Devil. (This was uncommon, particularly as there were fewer literate people). Left-handed people were therefore considered to be evil. Hence, the most common present-day meanings:
Threatening or portending evil, harm, or trouble; ominous: a sinister remark
Bad, evil, base, or wicked; fell: his sinister purposes
Unfortunate; disastrous; unfavorable: a sinister accident
Comes from the Latin Sinistra meaning lefthand
Think you should penalise the lefties