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@DFP
Dan, you mean like "overtraining" right?
The product of acumalated stress and inadequate recovery. Going on an extreme low calorie-low nutrient diet will barely leave one with the ability to recover from "life".
Hormones like cortisol will increase, to help more fat be stored, even when energy has to be sourced from muscle tissue. Hormones like testosterone will decrease, making one less energetic, weaker, loss of sex drive etc..
It will screw with mood aswell, many people go into a state of clinical depression when being overtrained like this.