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Not an expert, but generally you don't want to be firing rounds willy nilly.
I'd be surprised if you could safely shoot out tyres like in the movies without unintended consequences like rounds bouncing around the place.
I'm always struck by those US shooting stories where someone gets hit somewhere random like the leg, then the bullet deflects up into their internal organs or spine.
Couldn't they have shot the tyres? Then he'd have been totally unable to use the car as a weapon.