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100% it’s just the threads. It sounds like @youClown has the same use case as me. Thrash them to death. This is the replacement axle kit https://www.halowheels.com/shop/spares/hub-spares/tk-hub-120mm-axle-kit/ they are just M10 so a tap would be a cheap as chips. As are the nuts.
Why do they do this? I think it’s just we don’t look after them and well that’s the only reason. That and you always tighten the drive side nut a bit more than the non drive side.
Mavics are good because you can pop a hex key in the end of the axle to remove the nut.
Chaley-
Thanks - very reassuring. Mainly concerned with not being able to do roadside repairs but as long as it's just the drive side I'll content myself with just undoing that one first and replacing the axle and locknuts when the issue worsens.
@M_V likewise I thought it was an issue of the knurling wearing down!
youClown
IMO it’s none of the three things you mention. Rather just shitty threads on the axle and nut. And maybe wear to the knurling on the locknut.
Mavics do it a lot, American Classics are terrible for it though they have a slightly different, female axle/bolt set up.
New nuts might help, new axle and nuts and lock nuts probably the best way to sort it.
If you can figure out the axle thread diameter and pitch then you might be able to find an lbs with a die or just buy one off eBay. That and new nuts maybe the most cost effective?