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t.o.
Domino and rafix, no clamps required, everything can be assembled on site without glue. Also works well for freestanding furniture.
https://www.hafele.co.uk/en/product/connector-housing-plastic-rafix-20/P-00861352/
Screwing boards into the edge of boards is pretty basic. There are advantages in screws developed to do it but modern MDF is so fluffy in the centre there's barely anything for a screw to hold onto.
Domino is easily worth it for a professional, biscuit joints are a more accessible method if you can't justify the domino. Biscuit joints + screws can work ok.