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Odd - I've never not been able to pick up something I didn't already have i don't think. That said it does sort of try to restrict you from being too gung-ho. The guns are pretty weak and completely ineffective against the xenomorph and some androids. A shooter it ain't. Also if you play at harder levels things like the flamethrower for warding off the Xeno quickly becomes less and less effective.
Re playing Alien Isolation. So good.