Don't you feed brake and rear derailleur into that hole? In that case it would make sense to swap between mechanical / Di2 / eTap.
Electric only. At least on this one.
Edit: And bear in mind that even Di2 from now on is wireless on the front half so doesn't need a hole in the downtube
Edit edit: Though I will be having a di2 hole in the downtube. It can double duty for dynamo
@PhilDAS started
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Don't you feed brake and rear derailleur into that hole? In that case it would make sense to swap between mechanical / Di2 / eTap.