I’ve been running this, (outer ring, road chain line) and been fine for about a year, with a standard fixed hub... been alright so far! If that’s what you’re asking?
I'm actually thinking about a 1x10 drivetrain, but from my understanding, isn't the difference in chainline even bigger for fixed-outer double than cassette-outer double?
Depends what gear you’re in innit. I’ve been running 1x10 on road cranks, NW chainring in the big ring position (like everyone else). It’s just like only riding in the big ring - so no more or less wear than normal. Maybe a tiny bit more cross chaining but negligible I’d say.
I’ve been running this, (outer ring, road chain line) and been fine for about a year, with a standard fixed hub... been alright so far! If that’s what you’re asking?