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They're pricey (although I have an older model which is only about £100 and does the same job https://www.amazon.co.uk/Logitech-Harmony-Ultimate-software-required-Black/dp/B00C80JFSS ) but work very well.
Mine replaces remotes for TV, AV amp, Tivo, lights, Fire TV, Minidisc, Freeview, xbox, HTPC, HDMI switch and integrates into IFTTT and Alexa.
Setup is pretty easy and it's very customisable, you can even load up custom icons for the different activities, backgrounds, etc.
It means that someone can just press the button called "Watch TV" and it will turn on Amp, TV, HDMI switch and Tivo all to the correct input which means people other than me can actually watch TV.
Had a look at those Logitech harmony remotes, fuck me £200 for an all in one!!!
Got me itching for one though, running audio through an Av amp is a ball ache when you try to balance levels for Spotify/Netflix/usb stick in back of tv/ and PS4.