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Actually mathematically increasing the total flange spacing has a impact. In practice it works to.
So for lateral stiffness it is marginally better for the extra spacing to be on the nds. There is one 11 speed road hub u use with an asymmetric rim that has 16mm/49mm spacing. The resulting wheel is very stiff. Spoke tension balance is o.k and even with tubeless tyres mounted the rear nds spokes won't slacken off under load. I did a test wheel with the cooked vermicelli noodle that is known as the stans 340 in 24h drilling and sapim race spokes and the wheel is actually quite useable.
Still a rear disc brake hub generally has 54mm flange spacing or 55mm for the rear which is better than a DT Swiss road hub so your winning. And most 11 speed road hubs have 55mm spacing so no better really.
If we all went back to 7 speed or better 5 speed then we could have hubs with less dish which is mdcc testers point.
cycleclinic-
a rear disc brake hub generally has 54mm flange spacing for the rear which is better than a DT Swiss road hub
The big win with disc hubs is that the extra 5mm OLN means the DS flange can be 2.5mm further out for any given freehub rotor width
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If we all went back to 7 speed or better 5 speed then we could have hubs with less dish
Somebody on TTF suggested that once the manufacturers have got us all to buy into 1×12, they can start touting 3×5 as the new big thing. The proposition was that it would be based on greater drivetrain efficiency from straighter chain lines, but stronger wheels would be just as good a selling point :)
gbj_tester
The extra flange spacing, if any*, is on the NDS where there's already plenty on a disc hub. Deleting the rotor mount doesn't do anything for the DS where the actual problem lies.
*e.g. FH-M785 (disc) and FH-T780 (non-disc) have the same dimensions