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The chainstay is the only concern with the CAAD12, the rest is fine, and probably be enough for a 42mm even (2018 model now come with thru-axle fork and the housing go inside rather than on the side).
Working in a bike shop mean I can try and test it out, would love a fat tyred race bike.
Plus, where is your chain?
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@PhilDAS refuses to finish building any of his Cannondales
The chain stays get narrower. I very much doubt you’ll get a 38 in