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PhilDAS
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The chainstay is the only concern with the CAAD12, the rest is fine, and probably be enough for a 42mm even (2018 model now come with thru-axle fork and the housing go inside rather than on the side).
Working in a bike shop mean I can try and test it out, would love a fat tyred race bike.
Plus, where is your chain?
edscoble
Have anyone fitted 650b on their CAAD12 Disc yet?
Gonna order a CAAD12 Ultegra (2018) and see how big I can go with 650b tyres, hopefully at least 38mm.