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You don't need the brake calipers to be flat mount, but it will get the frame a "nicer look". They sell the frame with 160mm flat mount to post mount adapters (but then recommend the rear should be a 140mm... maybe asking them beforehand you can get a 140mm rear adapter like me)
This is what my frame came with:
And this is what they answered me about your question Aithein vs 4S:
The Mason Definition was my #1, since Dom was the designer of my previous Kinesis Decade Convert2, but he refuses to order a 62cm size (not enough buyers or some bullshit like that) and the Kinesis 4S Disc has almost the same geometry like the Convert2...
But you should have no problem with the size if the framesets arrive in time from the builders, anyway the claimed weight for the Mason Definition is about the same as the 4S Disc... I asked him and got this response:
A 60cm Definition frame weighs 1800g and the fork is 365g.
I've just came back for my first real ride with it, couldn't get into any serious climb/descent because of the weather (still snowing in the Sierra of Madrid), but the 160/140 brakes where really great and I'm using mechanical calipers (TRP Spyre).
The need for a 140 rotor its the only "problem" that I could see in the 4S, but with some decent rotors it should be good. Also the internal cable is a pain in the ass while building! but maybe it's just me that haven't built a bike in 4 years... and you can get someone to do the job.
The top tube internal routing (for a rim brake caliper) its really nice to guide the rear dynamo light cable (Supernova Tail Light). Also the lack of sloping in the top tube gives more room to use a framebag using along with a bottle cage dropper to be able to use 750ml or even 1l bidons
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Mason Definition is £895 and not available yet. Looks nice but this thing is going to get fucked up so buying a 'pretty' bike isn't on my todo list. I've mentioned Kinesis to Bike Whisperer so will see if they can source me one, otherwise CRC should be able to supply it and whatever else I need.
I'm going from rim brakes so 140mm probably won't make any difference to me. Do they suggest 140 on both front and rear or is it only the rear that has trouble fitting 140? So I could run 160 up front if I wanted to? Not even sure what flat mount is available in so the choice might be removed anyway.
I normally get someone else to build my bikes. Even if I wanted to (I don't) my flat is not really conducive to doing any serious work on bikes.
I used a small Deuter frame bag on PBP but don't really like frame bags. Anything that might cause me to change the way my knees track is a VERY BAD thing. The Apidura bags, for example, are way too wide for me to use. I'll likely have a top tube bag (maybe one near the seat post too) and large saddle bag. I've got some low-mount cages already that allow me to fit 1L bottles on my TT frame - @BringMeMyFix suggested the type to me years ago. I think my Elite cages also allow low mounting.
So, there's only 150-200g difference in frame weight between the models at the ~53cm size. Not sure what that will equate to at my 56/57cm size but it won't be all that much. Mudguard eyes are useful back in the UK when it's not being raced so the 4S wins on that front. It also wins on tyre clearance.
The 4S has Flat Mount disc mounts vs. Post Mounts. That's not going to make any difference I don't think. The 4S is cheaper and I already own the rim brake version of the 4S so I'm happy enough with the design already :)
Looks like the 4S has #1 spot.
Question then is, what bits do I then need for it?
Are these BR-785 units (http://www.bike-discount.de/en/buy/shimano-ultegra-di2-6870-st-r785-hydraulic-electric-kit-internal-internal-401953) Flat Mount and suitable for this frame? "It is best recommended that you run a 140mm rear rotor." say Kinesis. Ok!
I'll have a chat with my partner in grime tonight and see what the go is with ordering one.