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dglshrn-
Noticeably so, can be further improved by having a decent carbon seatpost.
The new 2016 Cannondale SuperSix now come with a 25.4mm seatpost, the previous Supersix have 27.2, further back to 2013, it used to have a whopping 31.6mm.
Oversized = stiffness usually, useful for frame, bar, stem etc. but with seatpost, you don't want to feel every small vibration travelling up your backside.
edscoble
It's 25.4, not 27.2.
The whole reason is that they're slightly more comfortable than a 27.2 seatpost, instead of having a little rubber block on the seat tube like Trek, they opt for a more traditional way of reducing vibration going up to your backside.
It's one of the many reason why I told @dancing james to get the Synapse.