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I had to rebuild a front wheel, which had a 2 x pattern not interlaced, built by a rather well known builder. The user came to me complaining that his front wheel was completely unreliable when turning into a corner and had lost confidence in the wheel and the builder... I was perplexed, as a 24 x 2 crossed Velocity A 23 front should be fine even with laser spokes... until I saw the spokes were not interlaced. I had an "exchange of ideas" with the builder who did the original job via e-mail, I think we both agreed to disagree and he probably thought I was an idiot, just in the same way I thought he was...
But being an idiot who is in the right is better than being an idiot who is in the wrong...
Never tried not interlacing be interesting to see what difference it makes. Novatec a171 f172 hubs are half the price of ultegra hubs. Spare are available. On that basis they are not a bad choice they are even reliable. You could always use miche rg2 hubs these are very reliable.