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No, it would just increase the reach slightly in a larger size, by about 15mm. Stem height wouldn't be affected, I don't think.
Going on the admittedly poor system of stack and reach, in a perfect world for my current flexibility I would have about 525 Stack and 360 Reach. Have fun finding that though.
I thought you need to be more flexible to go down a size given the stack ..
http://www.cyclingnews.com/features/pro-bike-mark-cavendishs-omega-pharma-quickstep-specialized-s-works-venge