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@andyp
"We designed this for a mountainbike drivetrain. We are running 42/28, with a 49.5mm chainline (between the middle rings). Weve also considered a 39/26 for lower speed pure offroad use. A road 46/36 or 50/34 will be too close to the frame and should not be used due to having a chainline 3-4mm narrower (which would take lots off the tyre clearance)."
From here.