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@Velocio
You'd have a problem on a derailleur if you never changed gear and put it in a pair of evens. Such pairings are fairly unavoidable when the cassette teeth vary by so little.
Which is why most derailleur set-ups will put a prime number on the most used chainring to solve the problem.
53 big ring was not chosen by accident, it's a prime number.
It's only ever going to be a problem if you sit in one gear the whole time though... and everyone changes gear some time.