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@Khornight2
Bit late to the big/big small/small debate, but something that's not been mentioned is small will mean a bigger jump if you have a flip flop hub and flip the wheel over by the same number of teeth.
For example my polo bike's road gear is 32x12 which is around the same gi as 42x16 and 44x17 (actually a bit higher than both), but compare the difference in gi's if you add four teeth (which I can easily fit on my dropouts without changing chain length):
32x12/16 = 17.9gi difference
42x16/20 = 14.0gi difference
44x17/21 = 13.2gi difference
As soon as I have a disc guard for my polo bike I'll be fixed with 3 brakes when riding on the road. :)