Science Squabbling

Probably not, as new Helium is being made all the time in the long alpha decay chains from heavy elements in rocks. It might become expensive, but that's not the same as running out. It's possible that high temperature superconductors might allow Nitrogen cooling in application currently using Helium, which will have a strongly adverse effect on your position, should you be thinking of investing in Helium futures :-)

Listen here from 21 minutes in: http://downloads.bbc.co.uk/podcasts/radio4/material/material_20120531-1800b.mp3

It's being made deep in the earth all the time, but it's only where it gets trapped by impermeable layers that it accumulates into more exploitable quantities, it's taken geological time to build up those quantities, and it's only when it shares those formations with natural gas that it's been economically feasible to collect it.

The current situation is the result of US government decisions. Around WW1 the US decided to accumulate a strategic reserve of helium, then in 1996 they decided to sell it off until they'd covered the cost of accumulating it. That started in 2003 and was about to stop, but they've decided to taper off the sale instead. http://news.sciencemag.org/2013/04/u.s.-house-passes-bill-would-head-massive-helium-shortage

Long term, once we run out of fossil hydrocarbons, we're out of cheap helium too. In the mean time we're probably wasting loads because it comes up with the natural gas, but people only bother to accumulate it in the few places where it's particularly concentrated. The helium market is pretty dysfunctional because it's piggybacked on the oil and gas industry. No idea if fracking can yeild helium.