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@Dry
I ride 48/17 and rich rides 49/17 round these routes all the time, the climbs are fine if you keep the momentum up but there is the option to swap to mellower climbs on the day if people are struggling. Kingy has dragged that disc wheel up Aston hill before so you should be fine.
Not a very hhsb thing to say but if anyone isn't very confident descending it might be worth putting a brake on if this route happens, I've tried to plan a route where the decents have plenty of run out but I don't want to be responsible for people coming off.