Fast road bike with disc brakes Di2, Columbus Zona, Custom Tokyo Fixed

no keeping the disc (Hope V twin) set up and would have to sell the rim brakes that come with Ultegra Di2 Groupset

Gotcha.

Cable pull disc would work fine with Shimano brifter, or just wait for that awesome TRP HY/RD brakeset.

I honestly think the Hope V Twin et all is OTT, as powerful as they are, they don't feel direct.