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@BareNecessities
We were initially concerned that it might have been FeLV [ame]http://en.wikipedia.org/wiki/Feline_leukemia_virus[/ame]
Which, being contagious, would have been an awful prospect in this house. Dottie thankfully tested negative for this and it now seems most likely to be a genetic condition.
We still have two of her brothers who both appear fine at the moment.