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@samsbike
From Harlesden, go towards the Car Supermarket, and instead of turning right, go past the roundabout and join the canal.
That will take you to St Johns Wood and to Edgware Road.
From there is its best just to ride the Euston Road to Gt Portland St.
You can do the Regents Canal but its busy and not as much fun.
There are some decent back roads on the south side of Marylebone road to get to Gt Portland road