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@BringMeMyFix
Should work alright. I've got a Tiagra standard that I changed to 47/39 (9spd setup), and a 105 compact that I changed to 50/38 (10spd setup). The 47t is a Gebhardt, and the 38t is some kind of generic/no-brand thing I can't remember.
Both work fine, though due to the stock 34t on the compact being dished towards the big ring, and replacing it with a non-dished item, I did have to angle in the rear of my front mech cage a little to retain crisp shifting and stop the occasional incidence of the narrow 10spd chain skating between rings on downshifts.
If going from 50 to 49, you might not even need to move the front mech down.