London to Brighton

toe overlap is generally only a problem at slow speeds when you are taking tight turns (such as filtering) so is unlikely to be a problem unless you are really planning on weaving all over the place slowly

Once you get outside london there is nowhere for you to experience toe over lap unless you have to make some sharp slow evasive manoeuvres which is not likely. It's a relatively quiet route as it shadows the M23 and is popular with cyclists so in terms of car traffic is pretty good.