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@gbj_tester
The widest point on a 50-559 (26x2.0 MTB) tyre is almost as far from the centre as the wide part of a 35-622 (700Cx35). You're likely to have trouble getting the tyre between the chainstays at least, maybe but less likely the seatstays, and probably the fork but that's easy to change for one with a wider crown. 650B are another 12.5mm bigger radius than 26", probably won't fit anywhere.