I can if it's directed at me* but if some c-unit tried doing that to my lady, he would be getting karate chopped in the throat.
Had an instance ages ago with a guy with family in the car, he was trying to push me out of primary and beeping, then he got past and I caught him at the lights looking furious, I just said to him "You are a horrible person" then looked at his wife and kids and rode off with a self satisfied glow ;)
I'm bitter and twisted. I'm waiting to use the line, "I hope one of your kids gets run over by a driver like you."