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For a range of crank lengths far wider than the narrow 165-180 range usually offered/used, there is no significant difference in biomechanical efficiency if gain ratio is held constant. See here for the most recent mainstream discussion of the matter.

"The saddle height (measured to the pedal) was maintained throughout and the researchers did not adjust fore-aft saddle position or handlebar height despite changes in pedal-to-knee relationship and handlebar drop with the various crank lengths. "

In real world use would you not adjust these for the rider?