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@dan
Remember reading the relative weights of the groupsets and 105 is by far the heaviest out of Veloce, Apex and 105.
Bit of a difficult question, but I suppose that having shimano/sram gives you LOADS more options in terms of wheel builds/factory builds, chains, etc etc. Campagnolo is good if you like it, but a little bit less flexible in terms of what you can pair it up with.