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@itsbruce
I don't think it is a good idea to run when you are tired; the chance of injuring yourself is much higher. Running is a high impact activity and good muscle tone and posture is important in protecting your joints and tendons. When you tire, the protection is gone and you're just asking to twist, stretch or tear something. If you do barefoot running, it's less risky because your feet won't let you push yourself the way cushioned trainers do, but it's still something to think through carefully.
Cycling when tired is a much less risky proposition, but being exhausted isn't a great way to live, so why not do some gentle cardio and rest up so that next week you can be fresh?