It obviously depends on how fast and flat the ride is, but I thought aero wheels only really made sense on bikes needing to stay over the regulation 6.5kg
The UCI limit is 6.8, but it's irrelevant; under pretty much any circumstance short of a UK-style hill climb, aero wheels trump light wheels in terms of the total energy needed to propel the bike over the whole course. Cervelo calculate that elite riders would need to be climbing >8% for the 200g penalty of an S3 frame to be a problem compared with the less aero R3, and frames make much less difference than wheels.
The UCI limit is 6.8, but it's irrelevant; under pretty much any circumstance short of a UK-style hill climb, aero wheels trump light wheels in terms of the total energy needed to propel the bike over the whole course. Cervelo calculate that elite riders would need to be climbing >8% for the 200g penalty of an S3 frame to be a problem compared with the less aero R3, and frames make much less difference than wheels.