start in the middle, loosen spokes away from the centre of it progressively (so inner most = 2 or 3 full turns, and outer most = 0.5 turn) etc.
Sounds like you have got a fair old size of flat there though, bit of experimenting will be worth the time to see how good you can get it.
If you get no-where with it, just shove a huge tyre on it so its slightly less noticable.
@BrickMan started
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start in the middle, loosen spokes away from the centre of it progressively (so inner most = 2 or 3 full turns, and outer most = 0.5 turn) etc.
Sounds like you have got a fair old size of flat there though, bit of experimenting will be worth the time to see how good you can get it.
If you get no-where with it, just shove a huge tyre on it so its slightly less noticable.