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@TheBrick(Tommy)
Agreed, Grand union canal all the way, I'd start near Uxbridge so you missed out the busy London section. Being as you are prepared to take two days over it this would make a lovely easy to to follow route with many nice pubs on route, I'm sure some of them will have rooms.
If you go for a nice country road route don't underestimate the time spent navigating, the canal route removes this problem.