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@AntoCuc
Agree 100%.
I started with 100km rides 75'' and got painful knees. Lowered to 63'' did a bunch of 100 and 200 rides, the other day I popped in the 75'' again and did a semi-hilly 100K in 4h.
I think it depends heavily on your fitness level/joints strength and how much you fancy enjoying the landscape whilst walking up a hill ;) .
I also realised that on 42x17 I have to eat and drink nearly double.