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@dubtap
I was riding for a couple of weeks with the upper of my Sidi Dominators pulling away from the sole unit at the ball of my foot which I think was causing my foot/ankle to pronate off vertical = really nasty knee twinges. Even 30 minutes riding was ending up uncomfortable. Never had any problem with knee before so hope new shoes will sort it.
Conversely I seem to have lucked out with my first proper road pedal setup with Shimano shoes/pedals. Zero pain/hotspots/numbness anywhere even after a really long day on the bike.