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@DFP
I believe it is possible to do the whole thing on canals.
But be prepared for canals during winter to be covered in mud & leaves in many spots aswell as having no lighting.
People Run it! :
http://www.gucr.co.uk/
also, google is your friend:
http://www.londoncyclist.co.uk/touring/cycling-from-birmingham-to-london/