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@ChrisNW
That looks like a chunky 25mm tyre!
I have run SKS guards with 25mm tyres on a racing frame. 10mm of clearance between the brake and the tyre should be enough to get a few mm gap between the guard and tyre.
Make sure you get the right width guard for the tyre size, larger widths may not fit between inside your brake caliper or frame between the chain stays.
As long as your wheels are true and tyres have minimal tread (so they don't get stones trapped) you can keep the guards really close to the tyre without any problem of fouling.