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@Kill
We hear a lot about mashing big gears being bad for your knee cartilage, Here's an Interesting article, something to consider if you ride a lot and sweat a lot, like me..If youre a lady on top (Jokes please) and predisposed to bone density issues anyway, supplementation seems to offer some benefits.
http://well.blogs.nytimes.com/2009/07/01/is-bicycling-bad-for-your-bones/?em