Mavic Open Pro or CXP33?

We use Mavic open pros, open sports and IRD Cadence and Cadence Aero rims.

Mavic rims, nice and affordable, great reputation and reliable.

The IRD rims you pay a bit more for, however, they are stiffer and lighter. I have Cadence on my road bike and for climbing in Mallorca, excellent, light, nippy, a joy to ride.

We use RoadAce Components to build our wheels, Steve is the guy who is the builder.

I am considering a IRD Cadence Road to a low-flange hub build. 28 2x or 3x front / 32 3x rear. Would you say the low-flange would be a bad idea with these rims? would they lack stiffness and strength?