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@TheBrick(Tommy)
Well if something has really changed in the area like a new set of offices near hence changing the skill set of the people able to live in that area (places now connected to C.W such as Deptford and the DLR ticks both these boxes) or a new transport link than yes the area will permanently change in some way. If not it may just be a temporary change unless the area they have moved from has experienced the change in transport / employment area stated in the first sentence. Hackney I would say satisfies this criteria.
I think there can be one degree of separation but two and the link becomes a bit weak.