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@stanpike
You've probably worked out your best route now but I cycle Harlesden - Farringdon and tried using the canal but you keep having to come off or stop for pedestrians or dodge crackheads under bridges, it's neither fast nor pleasurable. I find Harrow Rd/Marlyebone Rd/etc is the best way but it depends how much you enjoy riding in traffic, otherwise try going through Maida Vale and round Regents Park.