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@unxetas
I live and ride in a pretty much flat area and 48x18 works great for me. I had 48x16 before and didn't complain, but I can see that 48x18 is much easier on the knees. I get to work less tired than I used to, but it takes me a bit more time (probably because I'm not spinning faster).
I think the new ratio is easy enough to pedal around on flat routes, 44x18 would be a bit lighter than ideal, me thinks...