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@pip
There are lots of bikes out there with ISIS bottom brackets (ie last five years of or so of Bianchi Pistas). My lady's bike has an ISIS bottom bracket and its been working well for years. Lots of new off-the-shelf fixies come with Powerspline BBs so for the majority of folks they work ok.
Where you start getting into trouble is if you're really hard on equipment - if I was a brakeless messenger for example I may want to avoid splined stuff (more because its a pain to replace due to the different systems out there - Octalink, ISIS, Powersplines etc).
The first generation Octalink had a problem where the interface wore when skidding and cranksets failed. Haven't seen too many other failures in splined BBs apart from people who beat the living daylights out of their gear.