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Yes, I find them very comfortable (take a little bit getting used at first , with the feel of wearing them).
In my experience, they help against blisters, which definitely helps with running further, longer.
They ( Injinji branded toe socks and only brand I've tried) are also used by Courtney Dauwalter (one of the best trail runners in the world) and that sold them for me.
https://feetus.co.uk/product-category/toe-socks/injinji-socks/injinji-trail/
On another note, for keeping feet in good condition especially in winter and getting soaked- I recently started to use Gehwol foot cream, brilliant stuff and strengthens skin and protects against water damage
Should I be trying toe socks?