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Yes exactly - elevated PSA and enlarged prostate can both be attributable to other non-cancer related causes, leaving biopsy as current standard of care for confirmatory testing, which is in itself inherently risky to perform, and the new study aims to compare it to newer diagnostic tools like fast MRI etc
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Yes, I think wife says something like all men over 80 (or maybe 90 I can't remember) probably have prostate cancer.
A lot of hospitals have started doing prostate MRIs which are much better than traditional methods for detection.
Also, one for us bike riders, don't ride bikes for a couple of days before PSA test (or have sex/masturbate) because that can all give false high PSA.
Obviously recognise age and family history would place me in a high risk group but would prefer to hedge my bets on seeing the outcome of the soon to start TRANSFORM study comparing risk benefit of a number of existing and new diagnostic and treatment options. Should be 3 years until they get the results from the first patient cohort of 12500 men in UK, then another 300000 men into next cohort but first results of that probably a decade away or so I think